Oprah Winfrey

as Self (archive footage)

as Self - Host

as Self

as Self - Host

as Self

as Self - Guest

as Self

as Self

as Self

as Self (archive footage)

as Self

as Self

as Self (archive footage)

as Self

as Self

as Self

as Self

as Self (archive footage)

as Self

as Self - Host

as Mrs. Which

as Self

as Deborah Lacks

as Self

as Self (archive footage)

as Self

as Self (archive footage)

as Annie Lee Cooper

as Self - TV Host (archive footage)

as Gloria Gaines

as —

as Self

as Oprah

as Eudora (voice)

as Judge Bumbleton (voice)

as Oprah Winfrey

as Self (archive footage)

as Gussy the Goose (voice)

as Narrator (voice)

as —

as Self

as Self

as Self

as Coretta Scott King (voice)

as Sethe

as Zora Williams

as Self

as Elizabeth Keckley (voice)

as Oprah Winfrey

as Sofia